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O-methyl nakafuran-8 lactone, a new sesquiterpenoid from a hainan marine sponge Dysidea sp.

ע⣺ՓJournal of Asian Natural Products Research, 2006, 8(3):223-227l
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Z.Y. SHAO(־), J. LI, C.J.SIM,J.Y.LI, Z.Y.LI, F.J.NAN and Y.W. GUO
State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological
Sciences, Chinese Academy of Sciences

AbstractA new sesquiterpenoid,O-methyl nakafuran-8 lactone(1) has been isolated from a Hainan sponge Dysidea sp.and the strutrure of the new compound proposed by sectral data, was continued by X-ray dirrraction analysis. The complete 1H and 13C-HMR assignments were made on the basis of detailed 2D NMR spectral analysis. Compound 1 showed strong inhibitory bioactivity against PTP1B with IC50 value 1.58 uM.
Keywords: Dysidea sp; Sesquiterpenoid; O-methyl nakafuran-8 lactone

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