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SDwFokλcBchȺض׸ԵPϵ

ע⣺ՓڡwܲWs־, 2007, 17(8):448-451l
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1 ,A1 ,2 ,1 ,SԷ1 ,X1
(KϾ: 1. ϾWtWԺٿǻtԺ, 210008;
2. ϾWtWԺRWԺϾ܊^ϾtԺ, 210002)

ժҪ:Ŀ:̽ӑSD w(VDR) FokλcBchȺض (CP) ׸ԵPϵ:Ѽhضײ71,50ܽ錦սM,o }ѪȡMDNA,þۺø朷- ƬLȶB( PCR - RFLP)yFok, Mgͺ͵λlʵIJY: CPMĻͷֲr: FF (24, 33. 8% ) , Ff (38, 53. 5% ) ff (9, 12. 7% ) ,սM: FF ( 9, 18% ) , Ff ( 26, 52% ) ff ( 15, 30% ) , Mg^@Բ(2 = 7. 14, P = 0. 028) CPMλlʞF (60. 6% ) , f (39. 4% ) ,սMF (44% ) , f (56% ) ,Mg^@Բ (2 = 6. 48, P = 0. 011) FF( Ff + ff)OR = 2. 33 (95%CI = 0. 97 - 5. 57) ; Fλf OR = 1. 95 (95%CI = 1. 16 - 3. 28) YՓ:VDRFokλcBchض׸Կܴ һ“ϵ
PI~: SDw; B; ; ׸
[ЈD̖] R781. 4[īIRa]A [¾̖]1005 - 2593 (2007) 08 - 0448 - 04

Association of vitam in D receptor gene fokpolymorphism with moderate to severe chron ic per iodontitis of han nationality

LI Sheng3, YANGMing - hua, WANG Yu - cai, WU Wen - lei, HUANG Xiao - feng, QIAN Hai - feng
( 3 Affiliated Stomatology Hospital, Medical School, Nanjing University, Nanjing 210008, China)

ABSTRACT:A IM : To investigate the association of vitamin D recep tor gene Fok polymorphism with moderate to severe chronic periodontitis of Han Nationality. METHODS: A restriction fragment length polymorphism (RFLP) for Fok of the VDR gene was analyzed by polymerase chain reaction ( PCR) , followed by restriction digestion with Fok and gel electrophoresis. The genotypes of 71 moderate severe cases of periodontitis and 50 controlswith no periodontitis were analyzed. RESULTS: The genotype distribution in the patient group were 24 ( 33. 8% ) , 38 (53. 5% ) and 9 (12. 7% ) and in the control group were 9 (18% ) , 26 (52% ) and 15 (30% ) for FF, Ff and ff respectively. Allele frequencies were 60. 6% and 39. 4% for F and f in the patient group; 44% and 56% in the control group. Chi square analysis indicated that the distribution of the genotypes and alleles between these two group swere sig nificantly different ( P = 0. 028, P = 0. 011, respectively). The F allele seemed to increase suscep tibility to chronic periodontitis (OR = 1. 95, 95%CI = 1. 16 - 3. 28). CONCLUS ION: It indicated that okpolymorphism of VDR gene was associated with chronic periodontitis of Han nationality.
Key words :vitamin D recep tor; polymorphism; chronic periodontitis; suscep tibility

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